Can launch D3 normally but get D3D error through IS

As per the title, I can launch D3 normally both through the Battle.net launcher and a shortcut to Diablo III.exe -launch but after following the quick setup guide for D3 regardless of if I select "Diablo III - Skip Launcher", "Character set" or any of the "Set slot" in IS, I see the Diablo III RoS logo then a whiteish screen the same size as I selected in the display settings and an error message saying "Diablo III was unable to initialize D3D. Click OK to retry."

ISConsole: http://pastebin.com/B8rRZCGD
ISBoxer Diagnostics Report for Diablo III.exe: http://pastebin.com/uH0Vzqat
DxDiag: http://pastebin.com/93z5YY6i

Running updated Win10 and latest graphics drivers, GeForce 353.82.

Thanks for your assistance.

EDIT:
It seems that Spacedesk (http://spacedesk.ph/) is incompatible with ISBoxer, I uninstalled, rebooted and IS worked first time.

[bob]

latest graphics drivers, GeForce 353.82

The latest driver release is 368.69. You are about a year out of date.

Although I'd say your problem is Spacedesk hooking the game.

Code:

47. C:\WINDOWS\SYSTEM32\spacedeskHookLdr.dll [9.17.10.285] [datronicsoft] [TODO: <File description>]

Shut it down and see what happens.

And you might want to remove the HIGHDPIAWARE flag for D3.

Code:

Application Compatibility flags under HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers:
0 C:\Users\Public\Public Games\Diablo III\Diablo III.exe: HIGHDPIAWARE

it will probably give you issues later with Window positioning.

latest graphics drivers, GeForce 353.82

The latest driver release is 368.69. You are about a year out of date.

It seems you're correct, well latest drivers according to GeForce Experience at any rate.

Although I'd say your problem is Spacedesk hooking the game.

Code:

47. C:\WINDOWS\SYSTEM32\spacedeskHookLdr.dll [9.17.10.285] [datronicsoft] [TODO: <File description>]

Shut it down and see what happens.

Already figured that out and solved my issue, had edited my first post to reflect this.

And you might want to remove the HIGHDPIAWARE flag for D3.

Code:

Application Compatibility flags under HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers:
0 C:\Users\Public\Public Games\Diablo III\Diablo III.exe: HIGHDPIAWARE

it will probably give you issues later with Window positioning.

I'll adjust this, thanks for the heads up.