Same problem here. ISBoxer won't work for last day or two since it patched. One or two clients launch then was getting the following messages :

and later :

PC has over 200 Gb free on HD and 12 Gig of RAM. Have installed latest NVidia Drivers but this made no difference.
Running Win 7 64 bit. Set WoW to launch in 32 bit as requested and generated report from ISBoxer Diags :
[spoiler]
ISBoxer Diagnostics Report generated 27/07/2013 15:40 by ISBoxer 41.4.608.1
Running processes:
1. AEADISRV - Process ID: 1728
2. armsvc - Process ID: 1704 (C:\Program Files (x86)\Common Files\Adobe\ARM\1.0\armsvc.exe)
3. AsusAudioCenter - Process ID: 3272 (C:\Program Files\ASUS Xonar Essence STX Audio\Customapp\ASUSAUDIOCENTER.EXE)
4. audiodg - Process ID: 408
5. AvastSvc - Process ID: 1240 (C:\Program Files\AVAST Software\Avast\AvastSvc.exe)
6. AvastUI - Process ID: 3516 (C:\Program Files\AVAST Software\Avast\AvastUI.exe)
7. chrome - Process ID: 1184 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
8. chrome - Process ID: 1564 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
9. chrome - Process ID: 2760 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
10. chrome - Process ID: 4552 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
11. chrome - Process ID: 5308 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
12. chrome - Process ID: 5828 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
13. chrome - Process ID: 5876 (C:\Users\John\AppData\Local\Google\Chrome\Application\chrome.exe)
14. csrss - Process ID: 432
15. csrss - Process ID: 528
16. daemonu - Process ID: 2240 (C:\Program Files (x86)\NVIDIA Corporation\NVIDIA Update Core\daemonu.exe)
17. DHSClient - Process ID: 3768 (C:\Program Files (x86)\Virgin Media\Digital Home Support\DHSClient.exe)
18. dllhost - Process ID: 5996
19. DTLite - Process ID: 3136 (C:\Program Files (x86)\DAEMON Tools Lite\DTLite.exe)
20. dwm - Process ID: 2580
21. explorer - Process ID: 2604
22. HiPatchService - Process ID: 1836
23. HsdService - Process ID: 1920 (C:\Program Files (x86)\Virgin Media\Digital Home Support\HsdService.exe)
24. HsMgr - Process ID: 2900 (C:\Windows\SysWOW64\HsMgr.exe)
25. HsMgr64 - Process ID: 3076
26. InnerSpace - Process ID: 5628 (E:\Program Files (x86)\InnerSpace\InnerSpace.exe)
27. ISBoxer Toolkit - Process ID: 848 (E:\Program Files (x86)\InnerSpace\ISBoxer Toolkit.exe)
28. jucheck - Process ID: 2928 (C:\Program Files (x86)\Common Files\Java\Java Update\jucheck.exe)
29. jusched - Process ID: 3800 (C:\Program Files (x86)\Common Files\Java\Java Update\jusched.exe)
30. lsass - Process ID: 592
31. lsm - Process ID: 600
32. mdm - Process ID: 364 (C:\Program Files (x86)\Common Files\Microsoft Shared\VS7Debug\mdm.exe)
33. NIHardwareService - Process ID: 1616
34. nvSCPAPISvr - Process ID: 860 (C:\Program Files (x86)\NVIDIA Corporation\3D Vision\nvSCPAPISvr.exe)
35. NvTmru - Process ID: 3088 (C:\Program Files (x86)\NVIDIA Corporation\NVIDIA Update Core\NvTmru.exe)
36. nvtray - Process ID: 3604
37. nvvsvc - Process ID: 1304
38. nvvsvc - Process ID: 836
39. nvxdsync - Process ID: 1296
40. PnkBstrA - Process ID: 2284 (C:\Windows\SysWOW64\PnkBstrA.exe)
41. SASCore64 - Process ID: 1680
42. SDFSSvc - Process ID: 2316 (C:\Program Files (x86)\Spybot - Search & Destroy 2\SDFSSvc.exe)
43. SDTray - Process ID: 3912 (C:\Program Files (x86)\Spybot - Search & Destroy 2\SDTray.exe)
44. SDUpdSvc - Process ID: 2776 (C:\Program Files (x86)\Spybot - Search & Destroy 2\SDUpdSvc.exe)
45. SDWSCSvc - Process ID: 3540 (C:\Program Files (x86)\Spybot - Search & Destroy 2\SDWSCSvc.exe)
46. SearchIndexer - Process ID: 5072
47. ServiceManager - Process ID: 3640 (C:\Program Files (x86)\Virgin Media\Service Manager\ServiceManager.exe)
48. ServicepointService - Process ID: 2940 (C:\Program Files (x86)\Virgin Media\Service Manager\ServicepointService.exe)
49. services - Process ID: 584
50. smax4pnp - Process ID: 3492 (C:\Program Files (x86)\Analog Devices\Core\smax4pnp.exe)
51. smss - Process ID: 312
52. SoundMAX - Process ID: 2788 (C:\Program Files (x86)\Analog Devices\SoundMAX\SoundMAX.exe)
53. spoolsv - Process ID: 1556
54. SpotifyWebHelper - Process ID: 3256 (C:\Users\John\AppData\Roaming\Spotify\Data\SpotifyWebHelper.exe)
55. SUPERAntiSpyware - Process ID: 3320
56. svchost - Process ID: 1012
57. svchost - Process ID: 1148
58. svchost - Process ID: 136
59. svchost - Process ID: 1584
60. svchost - Process ID: 1768
61. svchost - Process ID: 2976
62. svchost - Process ID: 3208
63. svchost - Process ID: 388
64. svchost - Process ID: 4340
65. svchost - Process ID: 448
66. svchost - Process ID: 5228
67. svchost - Process ID: 752
68. svchost - Process ID: 904
69. System - Process ID: 4
70. taskeng - Process ID: 920
71. taskhost - Process ID: 2524
72. TrustedInstaller - Process ID: 2492
73. WajamUpdater - Process ID: 3028 (C:\Program Files (x86)\Wajam\Updater\WajamUpdater.exe)
74. wininit - Process ID: 516
75. winlogon - Process ID: 676
76. WLIDSVC - Process ID: 3064
77. WLIDSVCM - Process ID: 2612
78. WmiPrvSE - Process ID: 4456 (C:\Windows\sysWOW64\wbem\wmiprvse.exe)
79. WmiPrvSE - Process ID: 4508
80. WmiPrvSE - Process ID: 4680
81. wmpnetwk - Process ID: 2156
82. Wow - Process ID: 4732 (E:\Games\World of Warcraft\WoW.exe)
Modules loaded by Wow - Process ID: 4732 (E:\Games\World of Warcraft\WoW.exe):
1. E:\Games\World of Warcraft\WoW.exe
2. C:\Windows\SysWOW64\ntdll.dll
3. C:\Program Files\AVAST Software\Avast\snxhk.dll
4. C:\Windows\syswow64\KERNEL32.dll
5. C:\Windows\syswow64\KERNELBASE.dll
6. C:\Windows\syswow64\USER32.dll
7. C:\Windows\syswow64\GDI32.dll
8. C:\Windows\syswow64\LPK.dll
9. C:\Windows\syswow64\USP10.dll
10. C:\Windows\syswow64\msvcrt.dll
11. C:\Windows\syswow64\ADVAPI32.dll
12. C:\Windows\SysWOW64\sechost.dll
13. C:\Windows\syswow64\RPCRT4.dll
14. C:\Windows\syswow64\SspiCli.dll
15. C:\Windows\syswow64\CRYPTBASE.dll
16. C:\Windows\system32\Secur32.dll
17. C:\Windows\syswow64\WININET.dll
18. C:\Windows\syswow64\api-ms-win-downlevel-user32-l1-1-0.dll
19. C:\Windows\syswow64\api-ms-win-downlevel-advapi32-l1-1-0.dll
20. C:\Windows\syswow64\api-ms-win-downlevel-shlwapi-l1-1-0.dll
21. C:\Windows\syswow64\shlwapi.DLL
22. C:\Windows\syswow64\api-ms-win-downlevel-version-l1-1-0.dll
23. C:\Windows\system32\version.DLL
24. C:\Windows\syswow64\api-ms-win-downlevel-normaliz-l1-1-0.dll
25. C:\Windows\syswow64\normaliz.DLL
26. C:\Windows\syswow64\iertutil.dll
27. C:\Windows\system32\WINMM.dll
28. C:\Windows\system32\d3d9.dll
29. C:\Windows\system32\d3d8thk.dll
30. C:\Windows\system32\dwmapi.dll
31. C:\Windows\syswow64\IMM32.dll
32. C:\Windows\syswow64\MSCTF.dll
33. C:\Windows\system32\MSACM32.dll
34. C:\Windows\syswow64\WS2_32.dll
35. C:\Windows\syswow64\NSI.dll
36. C:\Windows\system32\DINPUT8.dll
37. C:\Windows\syswow64\SHELL32.dll
38. C:\Windows\syswow64\ole32.dll
39. C:\Windows\system32\IPHLPAPI.DLL
40. C:\Windows\system32\WINNSI.DLL
41. C:\Windows\syswow64\CRYPT32.dll
42. C:\Windows\syswow64\MSASN1.dll
43. C:\Windows\system32\WINHTTP.dll
44. C:\Windows\system32\webio.dll
45. C:\Windows\syswow64\SETUPAPI.dll
46. C:\Windows\syswow64\CFGMGR32.dll
47. C:\Windows\syswow64\OLEAUT32.dll
48. C:\Windows\syswow64\DEVOBJ.dll
49. C:\Windows\system32\apphelp.dll
50. C:\Windows\AppPatch\AcSpecfc.DLL
51. C:\Windows\WinSxS\x86_microsoft.windows.common-controls_6595b64144ccf1df_5.82.7601.17514_none_ec83dffa859149af\COMCTL32.dll
52. C:\Windows\system32\mscms.dll
53. C:\Windows\system32\USERENV.dll
54. C:\Windows\system32\profapi.dll
55. C:\Windows\system32\DDRAW.dll
56. C:\Windows\system32\DCIMAN32.dll
57. C:\Windows\system32\MPR.dll
58. C:\Windows\syswow64\COMDLG32.dll
59. C:\Windows\system32\msi.dll
60. C:\Windows\system32\api-ms-win-downlevel-advapi32-l2-1-0.dll
61. C:\Windows\syswow64\api-ms-win-downlevel-ole32-l1-1-0.dll
62. C:\Windows\WinSxS\x86_microsoft.windows.common-controls_6595b64144ccf1df_6.0.7601.17514_none_41e6975e2bd6f2b2\comctl32.dll
63. C:\Windows\system32\mswsock.dll
64. C:\Windows\System32\wshtcpip.dll
65. C:\Windows\System32\wship6.dll
66. C:\Windows\syswow64\urlmon.dll
67. C:\Windows\system32\api-ms-win-downlevel-shlwapi-l2-1-0.dll
68. C:\Windows\system32\DNSAPI.dll
69. C:\Windows\syswow64\CLBCatQ.DLL
70. C:\Windows\system32\dhcpcsvc.DLL
71. C:\Program Files (x86)\Common Files\Microsoft Shared\Windows Live\WLIDNSP.DLL
72. C:\Windows\syswow64\PSAPI.DLL
73. C:\Windows\system32\dhcpcsvc6.DLL
74. C:\Windows\system32\rasadhlp.dll
75. C:\Windows\System32\netprofm.dll
76. C:\Windows\System32\nlaapi.dll
77. C:\Windows\system32\CRYPTSP.dll
78. C:\Windows\system32\rsaenh.dll
79. C:\Windows\system32\RpcRtRemote.dll
80. C:\Windows\System32\fwpuclnt.dll
81. C:\Windows\System32\npmproxy.dll
82. C:\Windows\system32\uxtheme.dll
83. C:\Windows\syswow64\WINTRUST.dll
84. C:\Windows\system32\nvd3dum.dll
85. C:\Windows\SysWOW64\HsSrv.dll
86. C:\Windows\SysWOW64\DSOUND.dll
87. C:\Windows\SysWOW64\POWRPROF.dll
88. C:\Windows\system32\msiltcfg.dll
89. C:\Windows\SysWOW64\SFC.DLL
90. C:\Windows\system32\sfc_os.DLL
91. C:\Windows\system32\nvapi.dll
92. C:\Program Files (x86)\NVIDIA Corporation\3D Vision\nvStereoApiI.dll
93. C:\Program Files (x86)\NVIDIA Corporation\3D Vision\nvSCPAPI.dll
94. C:\Windows\system32\ntmarta.dll
95. C:\Windows\syswow64\WLDAP32.dll
96. C:\Windows\System32\MMDevApi.dll
97. C:\Windows\System32\PROPSYS.dll
98. C:\Windows\system32\AUDIOSES.DLL
99. C:\Windows\system32\wdmaud.drv
100. C:\Windows\system32\ksuser.dll
101. C:\Windows\system32\AVRT.dll
102. C:\Windows\system32\msacm32.drv
103. C:\Windows\system32\midimap.dll
Application Compatibility flags under HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers:
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3.exe: WINXPSP3 RUNASADMIN
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3x.exe: WINXPSP3 RUNASADMIN
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3y.exe: WINXPSP3 RUNASADMIN
0 C:\Windows\SysWow64\cmicnfgp.dll:
Application Compatibility flags under HKEY_CURRENT_USER\SOFTWARE\Microsoft\Windows NT\CurrentVersion\AppCompatFlags\Layers:
0 C:\Games\Ultima Online Classic\client.exe: WINXPSP3 DISABLEDWM RUNASADMIN
0 C:\Program Files (x86)\Razor\Razor.exe: RUNASADMIN
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3.exe: WINXPSP3 RUNASADMIN
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3x.exe: WINXPSP3 RUNASADMIN
0 E:\Steam\steamapps\common\Age Of Empires 3\bin\age3y.exe: WINXPSP3 RUNASADMIN
[/spoiler]