Sat Aug 05, 2017 7:51 pm by bob
Ok,
I'm assuming you meant GB for the paging file details rather than MB. If it really is MB, try setting some larger values, with a minimum of 1GB (1024MB).
The amount of RAM you've indicated should not have allocation errors. Certainly not on x64 system, unless you are physically running out of ram, which seems unlikely as I'm guessing you have 24GB.
So the two things that stand out are IOBit and Synerygy. For testing purposes can you try without Synergy running (yes I realise you probably use this to manage the multiple PC's). The other thing will be to uninstall IOBit, which I imagine you are less keen on. At the very least set some excludes in IObit on InnerSpace.exe and PathOfExile_x64.exe (unfortunately game updates do change the checksums on various files so if you had excludes before they are no longer valid - neither are the AV heuristic databases until they get updated).
Another question I guess is are the characters in the ISBoxer Profile set to use the "default profile" that you are testing with when launching this direct from the Inner Space menu? There is nothing that ISBoxer really does any differently, other than using the per character virtual files for each character (for Path of Exile this is called production_Config.ini). You could try backing up the existing production_Config-Charname.ini files that ISBoxer will have created, and relaunch. New ones will be created, so if there is something weird in it, then that would fix that up.
Beyond that, I think we'll have to try and replicate the issue. It is possible they've changed something in the internals of their graphics handling, but I cant think offhand what would cause that to occur when using ISBoxer vs the Inner Space profile. The sound thing just came up in a google about the error in conjunction with POE, and it was suggested by GGG devs.