Have to reinstall Innerspace after every game

So I stopped multiboxing for a while now, just recently started up again. Got everything working just fine, but now it seems that whenever I exit game (4boxing), when I want to play again my four copies of Diablo 3 refuse to all open. Only 1-3 will open before something hangs. Nothing seems to fix this other than uninstalling and reinstalling Innerspace and ISBoxer suite. Then everything works fine. Played some games, went to sleep, next day I want to play again and all my windows won't launch. Uninstall and reinstall again, works again. This is confusing me, to say the least.

[MiRai]

I'd suggest grabbing a diagnostic for crashes from the game instance that is hanging, and also sending Lax the dmp file for game freezes from that same instance.