I was just looking for obvious things. These days programs update themselves all the time, with and without informing you.
Take the below as you will. At this time we have 2 people out of all the ISBoxer EVE players reporting similar FPS issue scenarios. Unfortunately (for you that is) it doesn't appear to be playerbase wide, so it would appear to be more localised to your computer(s).
So, my assessment on the paste is:
Despite all the various Application Compatibility flags, nothing there looks to be a problem.
The only hook you have in the EVE Launcher is Avast, so you could try putting an exclude on that, as well as exefile.exe (i.e. do this in Avast so it doesn't do realtime protection scans/hooks - it will still scan these things with a full system scan)
Another final option would be to shutdown some/all the unnecessary stuff that you don't need to multibox. If it's an app or service you don't use, then get rid of it. There is many things running on your computer that might explain it.
If you don't absolutely need the following, shut them down, or uninstall.
- Code:
2. AISuite3.exe - Process ID: 4368 (C:\Program Files (x86)\ASUS\AI Suite III\AISuite3.exe) [Admin:YES] [x86] [1.0.0.0] [ASUSTeK Computer Inc.]
7. aswidsagenta.exe - Process ID: 7956 [Admin:??]
10. AvastSvc.exe - Process ID: 2524 [Admin:??]
11. AvastUI.exe - Process ID: 9788 (C:\Program Files\AVAST Software\Avast\AvastUI.exe) [Admin:NO] [x86] [17.4.3482.0] [AVAST Software] [Avast Antivirus]
12. BingSvc.exe - Process ID: 9352 (C:\Users\CLaw\AppData\Local\Microsoft\BingSvc\BingSvc.exe) [Admin:NO] [x86] [1.0.6.0] [© 2015 Microsoft Corporation] [Microsoft Bing Service]
17. DipAwayMode.exe - Process ID: 4268 (C:\Program Files (x86)\ASUS\AI Suite III\DIP4\DIPAwayMode\DipAwayMode.exe) [Admin:YES] [x86] [6/13/2014 5:44:52 AM]
27. EzUpdt.exe - Process ID: 4316 (C:\Program Files (x86)\ASUS\AI Suite III\EZ Update\EzUpdt.exe) [Admin:YES] [x86] [10/9/2014 1:30:30 AM]
33. GameBarPresenceWriter.exe - Process ID: 14988 (C:\Windows\System32\GameBarPresenceWriter.exe) [Admin:NO] [x64] [10.0.15063.0 (WinBuild.160101.0800)] [Microsoft Corporation] [Gamebar Presence Writer]
44. LWEMon.exe - Process ID: 9356 (C:\Program Files\Logitech\Gaming Software\LWEMon.exe) [Admin:NO] [x64] [5.10.127] [Logitech Inc.] [Logitech WingMan Event Monitor]
49. MSIAfterburner.exe - Process ID: 4280 (C:\OC Tools\MSI Afterburner\MSIAfterburner.exe) [Admin:YES] [x86] [4, 1, 1, 7625] [MSIAfterburner]
50. mylbx.exe - Process ID: 8800 (C:\Program Files\My Lockbox\mylbx.exe) [Admin:NO] [x86] [3.9.1.611] [FSPro Labs] [My Lockbox]
55. NVIDIA Share.exe - Process ID: 12012 (C:\Program Files (x86)\NVIDIA Corporation\NVIDIA GeForce Experience\NVIDIA Share.exe) [Admin:NO] [x86] [56.2924.1538.1] [NVIDIA Corporation] [NVIDIA Share]
56. NVIDIA Share.exe - Process ID: 12316 (C:\Program Files (x86)\NVIDIA Corporation\NVIDIA GeForce Experience\NVIDIA Share.exe) [Admin:NO] [x86] [56.2924.1538.1] [NVIDIA Corporation] [NVIDIA Share]
57. NVIDIA Web Helper.exe - Process ID: 12368 (C:\Program Files (x86)\NVIDIA Corporation\NvNode\NVIDIA Web Helper.exe) [Admin:NO] [x86] [6.9.5] [Node.js] [NVIDIA Web Helper Service]
58. nvspcaps64.exe - Process ID: 9248 (C:\Program Files\NVIDIA Corporation\ShadowPlay\nvspcaps64.exe) [Admin:NO] [x64] [3.6.0.74] [NVIDIA Corporation] [NVIDIA Capture Server]
59. nvsphelper64.exe - Process ID: 11868 (C:\Program Files\NVIDIA Corporation\ShadowPlay\nvsphelper64.exe) [Admin:NO] [x64] [3.6.0.74] [NVIDIA Corporation] [NVIDIA ShadowPlay Helper]
63. ProfilerU.exe - Process ID: 6472 (C:\Program Files\Saitek\SD6\Software\ProfilerU.exe) [Admin:NO] [x64] [6.0.5.12] [Saitek] [Saitek SST Profile Launcher]
64. PushNoticeMonitor.exe - Process ID: 8924 (C:\Program Files (x86)\ASUS\AI Suite III\Push Notice\PushNoticeMonitor.exe) [Admin:YES] [x86] [1.0.1.2]
65. PushNotify_PCCtrl.exe - Process ID: 6880 (C:\Program Files (x86)\ASUS\AI Suite III\Push Notice\PushNotify_PCCtrl.exe) [Admin:YES] [x64] [1.0.0.0] [PushNotify_PCCtrl]
66. PushNotifyServer.exe - Process ID: 4116 (C:\Program Files (x86)\ASUS\AI Suite III\Push Notice\PushNotifyServer.exe) [Admin:YES] [x86] [1.0.0.1] [ASUSTeK Computer Inc.] [ASUS Push Notice Server]
71. SaiMfd.exe - Process ID: 5792 (C:\Program Files\Saitek\SD6\Software\SaiMfd.exe) [Admin:NO] [x64] [6.0.5.12] [Saitek] [Saitek MFD File System Driver]
72. Samsung Magician.exe - Process ID: 8936 (C:\Program Files (x86)\Samsung\Samsung Magician\Samsung Magician.exe) [Admin:YES] [x86] [4, 5, 1, 65] [Samsung Electronics.] [Samsung Magician Application]
73. SamsungRapidApp.exe - Process ID: 6160 (C:\Program Files (x86)\Samsung\RAPID\CacheFilter\SamsungRapidApp.exe) [Admin:NO] [x64] [1.0.1.81 built by: WinDDK] [Samsung Electronics Co., Ltd.] [Samsung RAPID Mode Notification Utility]
74. SamsungRapidSvc.exe - Process ID: 3556 (C:\WINDOWS\system32\RAPID\SamsungRapidSvc.exe) [Admin:NO] [x64]
166. X55_Rhino_Profiler.exe - Process ID: 10108 (C:\Program Files\Mad Catz\X-55 Rhino\X55_Rhino_Profiler.exe) [Admin:NO] [x64] [7.0.41.10] [Mad Catz] [X-55 Rhino Profiler]
168. XtuService.exe - Process ID: 14276 (C:\Program Files (x86)\Intel\Extreme Tuning Utility\XtuService.exe) [Admin:NO] [x86] [5.2.0.14] [Intel(R) Corporation] [XtuService]
Note: some of these might be tricky to get shutdown, and others are a bit of a merry chase (usually uninstalling, and if needed a custom install to get only basic drivers or services back on). Some may even be required for you, depending on how your computer is configured. I can only report that they are unnecessary for actually running a basic install for testing.