You shouldn't be using the Launch with Inner Space button in the ISBoxer EVE Launcher (ISBEL), unless you are not using ISBoxer, but rather some other Inner Space system.
Next, double check your character settings in ISBoxer. I.e. select each character in the top left, and in the lower right, check that the Game is set to ISBoxer EVE Launcher, and the game profile is then set to ISBEL - <ACCOUNTNAME> as appropriate for that toon.
If that is all correct, then get a
compatibility diagnostic.