Question layout 5 chars in wow

I have 22" wide I have no problem setting it up the way i want, i wonder is it better to have 5 boxes on the right or 5 on the bottom? which way it gives you more space?

[MiRai]

You may want to lay all the windows on top of each other and look into using Video Feeds on your main layout or your second monitor (I
read your other post.) As for those FPS issues you're having on the second monitor, do you have multiple video cards installed?

When doing five/monitor (or six in LoTRO) I use 1280x800 main, 640x400 slave resolutions in the following layout:

222 333 444
222 333 444
1111111 555
1111111 555
1111111 BBB
1111111 BBB

(B is for blank area, i'm playing with video feeds in that area to drop a second mini-map for dual herb/mining tracking)