2 monitors and 2 video cards

Each graphic card render 1 monitor in a single machine, i will play 5 wow clients with 5 regions in one monitor (1 black spot that is swaped) and 1 region in the second monitor, big screen for main.
I will have any problems with swap becouse of different video card? or its best i do a non swapable setup? my second monitor is 22" so i dont think i will change much, 4 wow splited in 22" is still usable

Thanks in advance as always

Edit 1: i can use my account in my wife computer at same time my computer? same network and ip

[lax]

Each graphic card render 1 monitor in a single machine, i will play 5 wow clients with 5 regions in one monitor (1 black spot that is swaped) and 1 region in the second monitor, big screen for main.
I will have any problems with swap becouse of different video card? or its best i do a non swapable setup? my second monitor is 22" so i dont think i will change much, 4 wow splited in 22" is still usable

GPU Management discusses the multiple GPU problem.

The way it works is each game instance is going to be assigned a specific GPU when it is first launched. ISBoxer is going to do this based on your Window Layout. That GPU will be used to render that instance until it is closed, regardless of where you move the window. It's possible to switch GPUs, but doing so is costly.

As a consequence, if you move any window from one monitor to the other, you will see a steep performance hit as a constant drain on your FPS. This is on Windows XP, Vista, and 7 at least; I have not specifically tested this behavior on 8 yet but suspect it is the same as 7.

If you have 2 monitors, and each is powered by its own GPU, then when you use the Quick Setup Wizard or Window Layout Wizard, set Cross-monitor swapping to False. This will prevent any movement of windows from one monitor to the other, and avoid the performance hit. You can still choose from and customize many different possible layouts.

Edit 1: i can use my account in my wife computer at same time my computer? same network and ip

Yes, you and your wife can use your Lavish account on up to 5 of your own computers at your same physical location.