Using 12 accounts, I have 2 Orcas and 10 Hulks in a belt. One Orca is the dedicated booster and where all my miners dump their Ore. My Second Orca is just for hauling. I drag all the ore out of the booster's fleet hanger into the second Orca until it is full, then fly it to the POS or Station. If you are on the ball, you can easily haul everything out of a system to the next system, dump it and return before the boosing Orca is full again.
As for the Hulks... I have 2 for each Ore type. The first one starts at the closest roids, the second and the farthest. That accounts for the first 8 Hulks. The last 2 hulks I use on whatever ore there is most of. This allows me to completely clear an entire belt in a very short time.
Although I also have 20 active Accounts, the rest are dedicated PVP and not connected to my mining corp or my Alliance.
My screen layout is one main all the way across the top with 10 small windows across the bottom.
All my Hulks are Heavy Shield Tanked. I do not mine as fast, but I do not loose a lot of Hulks either. The last 7 man battleship suicide ganker fleet to hit me was only able to take out one 200 million ISK Hulk. I on the other hand was able to salvage 400 million ISK from their wrecks.
Still at this level mining, you do become a prime target, but you make a hell of a lot more than you loose.