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When I press for example shift+1 the debug output of my main window is:

Mapped Key: Pressing 'Shift+1' in 'ISB42 - Combat Broadcast'
Mapped Key: Releasing 'Shift+1' in 'ISB42 - Combat Broadcast'
Button: from keystroke@is2: nomodifiers 160+1

Debug from my second window is:

Button: from keystroke@is2: nomodifiers 160+1

So the second window wants to press "nomodifiers 160+1" which results in FF14 triggering just "1". Same result with ctrl and alt.

This is the mapping for ctrl+1:

You'll need the "Hold" option enabled on the Mapped Key for this game to recognize the modifiers you intended

I will try that, thank you.