Fri Dec 28, 2012 12:03 pm by lax
Someone else came to this thread with "the same issue"
So I guess it probably had nothing to do with my post above.
The issue in this thread is most likely that ISBoxer is copying the Cache. When the D3 logo comes up the very first time for each game instance, this will take a minute or two, and if you actually click on the D3 logo at the time it's going to pop up the "Not responding" box shown in the screenshot. Don't click on it, just be patient and wait for it to finish launching.
If it takes longer than 3 minutes to make the copy, then ISBoxer assumes something probably went wrong and waits for you to help. It's not a big problem, this is expected to take a couple of minutes. If it doesn't continue launching your team after the first game client finishes coming up correctly, just Launch your team again (the same way you did the first time) to continue the launching process.