Difference in screen resolution.

When i turn on key broadcasting and try to accept quests and turn them in and such the mouse is in different spots on ea window. I assume it is because the screens are not both the same aspect ratio. How can i fix this the layout is not custom its 1 of the premade layouts

[Alge]

In the Default Repeater Profile in ISBoxer, try one of the scaled settings for Cursor Positioning Mode. It won't be pixel perfect but it will probably be better than it is now. If you do want perfect broadcasting your Window Layout Regions will need to be the same aspect ratio and the in-game resolutions will need to be the same.