There are other issues still wrong with your profile that might cause oddities because you have multiple things bound to the same hotkey, and worse, they are the same action, so it ends up being called twice, which can cause issues (although I think your issue is the second one here). You could have solves this with a File -> Clear, and rerun the Quick Setup Wizard. That said, the issues are below.
1. Unbind the hotkeys here (they are already in ISB42 - Base Hotkeys, which ends up calling these).
2. You have changed the Assist bind for the ISBoxer macro key to NUM9. This is a bad choice as modifiers, such as CTRL/SHIFT/ALT do funny things to NUMPAD keys (which also do depend on the status of NUMLOCK too).
This is normally BACKSPACE in a default setup. You can either set it back, or if you use BACKSPACE for something else, you need to find a native "normal" key, that you are not binding to anything else in game, including all versions with modifiers.
If you make changes to the GameHelpers, you need to Export to InnerSpace to recreate the ISBoxer Addon, and additionally either reload the games from scratch, or do a /reload on all toons in game.