After having a look through the profile I am of the opinion you should clear it and start again (File menu, Clear, Yes to everything (except may characters), then Wizards, Quick Setup Wizard). Not through any major conflicts, but I suspect it will be easier to correct some of the changes you have made.
But. First you need to understand what Key Maps, and Mapped Keys are.
Key Maps: are groups or containers of Mapped Keys. They don't really do anything other than group a bunch of things together, which you can turn on and off as a bunch - not that you need to yet.
Mapped Keys: are tools that redirect of input. e.g. you press a key on the keyboard and something happens. You can also press other things too, like mouse buttons, headphone buttons, foot pedals etc. Something that provides input to a computer can be made to then generate some output to the game. Now the real clever thing with computers is that the input and the output results can be remapped to other things. This means you could remap the keyboard so when you press the PAGE UP key, it actually outputs the ENTER key. Or sometimes if you want to be really funny, you can remap all of the alphabet keys to output different alphabet keys. This annoys everyone who has been the butt of this joke.
What that got to do with anything? Everything it turns out. ISBoxer will allow you to configure these remappings via Mapped Keys so you can press the F key, and it will really send CTRL + ALT + SHIFT + F12, if that is what you wanted (I chose that example because it is an annoying combination to reach quickly). Sometimes you may want a remapping to actually send the same key as what you are pressing. This is referred to as a broadcast when it goes to all windows (not that it has to), but it is essentially a remapping, but just happens to remap with the output value the same as the input value.
So, all that said. Your follow problem probably comes from a couple of things. (Note: your hotkey shows up on my system as `, this may not be what you have on your keyboard, mine is a EN-GB layout).
1. You have ` as your hotkey (this is the key that you press, ISBoxer will intercept and send something to the game).
2. This then does 2 actions
2.1. Target Slot 1 (this should actually be "Target {SLOT}" so IF you happened to be on character 2 it would still work).
2.2. Run a Variable Keystroke called Follow Target and send the result to the game window. You have set the Follow Target value to be `. So your in game keybind for follow should also be `. As a general rule, it is recommended to leave the ingame keybinds on the defaults and not change them, unless you always change them to match your play style.
Second thing. You have also set the Follow Me mapped key to be "Hold any Keystroke Actions while Hotkey is held" to ON. This is a bit odd for the follow mapped key. This particular setting is normally used for mapped keys where all the keys should behave as though they are held down while you press the key. Like WASD for moving around; you don't normally have to press these to move, you press and HOLD them to move. When this is OFF the behaviour in ISBoxer is to send the resulting key to the game as a brief keystroke. The Follow Me mapped key is normally set to OFF, and the "Execute a Step when the Hotkey is " "pressed OR released". Which means that a step will be fired when the hot key is pressed (step 1, Target Slot) and then a second when it is released (step 2, Follow Target). Yes this does mean you actually get two key presses for the price of one.
The other thing that stands out is that you have set some Virtual Keystrokes on SLOT 1 of the character set. These are doubled up, although the same. I'm not sure the effect that this will have, but you probably shouldn't double them up.