Ok... I waited for additional updates to happen to see if that resolved the problem. Both my video driver was updated and isboxer as well.
If I run everquest.exe with my built in video card, everything runs fine (but slow because it's not as powerful). If I attempt to change things to use my NVidia card, what happens is that the game opens up in some sort of default location, and when isboxer corrects the location according to the region settings in window layout, the screen goes blank.
Things are still clickable and can be navigated with both mouse and keyboard, but you can't see anything but a blank window where the game should be. The game runs perfectly if I don't use isboxer.
I'm at a total loss... My integrated video card is not powerful enough to run my characters on one machine...
Alienware M17x r4, running 64-bit Windows 10 with an NVidia GTX-675M video card, and the latest drivers.
In addition, I don't know if it is related... But my GPU temp sensors are no longer monitoring the GPU temp.