Mouse sticking

I'm wondering if anyone is having issues with their mouse sticking? I'll be going one direction, then I'll switch and it wont go in the direction I told it to. It happens while quad boxing, as well as playing solo. I run all 4 games over 60 frames with no issues and had not had this problem since about two days ago. This may or may not be an ISboxer related issue but I'm curious if I'm not the only one. If anyone has any input it would be greatly appreciated; yes my visuals are all low on the lowest resolution with Vsync on, any generic troubleshooting has already been done. This does not happen anywhere but in D3.