Re: Just started trial, cannot run D3 through ISBoxer
After recently helping another user in the IRC chat for hours with a mysterious problem such as yours they eventually broke down and reinstalled Windows, and everything worked just fine after that. I know people don't normally want to hear that as a potential fix and I'd compare their diagnostic to yours to see if anything looked similar, but unfortunately their link has expired.
As a shot in the dark this might sound crazy, but if you have an Asus Xonar sound card you may have to uninstall the drivers from your system (and possibly remove it entirely from your motherboard so that it doesn't automatically reinstall itself) to see if it's the cause of the problem. If you don't have an Asus Xonar sound card, then I'm not sure what else you could do unless you can get Lax a game freeze or crash report of some sort.