Re: New patch problem !
Then we discovered more ways they broke things for some people, and we shared that information, including with you.
Unless something changed with your configuration, the current wisdom -- how do I get ISBoxer macros working after the WoW 10.0 patch -- has already been dispensed.
1. Update ISBoxer to the current version
2. Export to Inner Space (or the Addon will not be updated)
3. Make sure ActionButtonUseKeyDown is set to 0 once in game.
Beyond that, might I suggest saving your current profile (File, Save As, name it something else), then do a File, Clear and run the Quick Setup Wizard again?