Well, I did a search on my computer and found the files. They were located in the Innerspace folder where you would expect them to be. I honestly have NO IDEA why the program would 'forget' where it was. I have never installed any other copies of Inner space or changed the directory where it saves the file etc.
I have never changed anything from Inner space or ISBoxer since I installed them years ago. /boggle.
Anyway, ty for getting me back up and running. Once I pointed ISBoxer to the correct file location, all the settings were back where they should be.
Ty for your help