You stated in another thread that you resolved your issue, but I feel the need to say that the profile, as you have provided in this thread, is a gigantic mess.
1) You are mixing my old Pro System profile with a non-Pro ISB42 template, and this is going to cause nothing short of a headache.
2) You have Hotkeys assigned in several areas they should not be—Action Bar Key Map, Class-Spec Key Maps, and Virtualized Combat (not that those do anything).
3) You have re-used multiple Hotkeys across several different Key Maps. For example, the "2" key is used as a Hotkey in five different Key Maps: Combat Hotkeys, Paladin - Protection, ISB42 - Combat Broadcast Hotkeys, Warrior - Fury, and Virtualized Combat.
4) If you are attempting to use the Pro System, the majority of your characters are not assigned Virtual Mapped Keys at the Character level.
5) Several wizard-generated macros in ISBoxer are sharing Key Combinations (although not technically an issue at this time).
6) Class macro set is assigned to one of your Character Sets, rather than just characters of that class.
If you are unfamiliar with the basic setup of ISBoxer, then trying to use any of the profiles I've provided in the Pro System video series is unlikely going to help you, and I do not provide those profiles in the descriptions of certain videos so that they can be used as a starting template profile for new multiboxers. My recommendation is that you either clear your profile (File > Clear) or back it up (File > Save As), and start fresh with the standard
Quick Start Guide.